Why is my mouse scroll wheel not working smoothly?

Grime buildup around the wheel encoder. Clean around the scroll wheel with isopropyl alcohol and compressed air.

How do I clean a gaming mouse with RGB?

Same method. The RGB components are sealed. Just don't submerge the mouse.

Some gaming mice are designed for easy disassembly. Check your model. Otherwise, surface cleaning is sufficient.

Fabric pads: hand wash with mild soap and cold water, air dry flat. Hard pads: wipe with isopropyl alcohol.

Electronics

Your computer mouse need regular cleaning to perform well and last longer. Here's the safe way to do it without damaging sensitive components.

1
Disconnect the mouse
Unplug USB mice or turn off wireless mice. Remove batteries from wireless models.
2
Wipe the surface
Dampen a microfiber cloth with isopropyl alcohol and wipe the entire mouse exterior.
3
Clean the scroll wheel
Use a cotton swab with alcohol around and between the scroll wheel. Spin the wheel while cleaning to access all surfaces.
4
Clear the sensor
Turn the mouse over and gently clean the optical/laser sensor window with a dry cotton swab. Blow away debris with compressed air.

TIPThe scroll wheel is the dirtiest part of any mouse. Roll it while cleaning to access the full circumference.
TIPClean your mousepad too. A dirty pad transfers grime back to the mouse feet and sensor.
TIPAlcohol wipes make quick work of daily mouse cleaning at your desk.

XUsing water, which doesn't evaporate fast enough and can drip into the internal electronics.
XNeglecting the mouse feet/skates, where grime builds up and causes uneven tracking.
XSubmerging any part of the mouse in liquid.

Weekly wipe-down. Deep clean monthly. Clean the sensor and scroll wheel every 2 weeks.