A clean air ducts makes a bigger difference than you'd think. Here's the most effective method, plus the mistakes most people make.
Turn off the heat or air conditioning at the thermostat to prevent dust from spreading during cleaning.
Unscrew and remove the vent covers from each register. Wash them with warm soapy water.
Use the vacuum hose to reach as far into the ducts as possible. Suction out dust and debris.
Use a damp microfiber cloth on the end of a stick to wipe the inside of the ducts as far as you can reach.
Install a new furnace filter while the system is off. This is critical for air quality.